For optimal absorption, Cenforce 100 should be taken with plain water. Water helps the body process the medication quickly without interfering with its effects. Some juices—especially grapefruit juice—can interact with sildenafil, potentially increasing side effects or altering the drug’s effectiveness. Citrus juices may also affect how the liver metabolizes the medication, leading to slower absorption or higher drug levels in the blood. To ensure safety and consistent results, avoid juices and stick to a full glass of water. Always follow medical advice for the best and safest experience with Cenforce 100.